UpToDate UpToDate is an electronic clinical decision support resource, available online or through highly-rated mobile Apps for most leading platforms. UpToDate is unique because it offers continuously updated recommendations based on the most current medical evidence available, written and reviewed by more than 6,900 leading physicians worldwide. UpToDate content spans 25 specialties, at the level of the sub-specialist, and includes easy-to-search graphics and a drug database and drug interactions tool (in partnership with Lexicomp®).